Hypermethylated in cancer 1
Web14 apr. 2024 · Considering the distribution of the DM CpGs in relation to CpG islands, compared with the overall distribution of analyzed CpGs, we found enrichment for hypermethylated CpGs at CpG islands in the comparison of metastases with normal … Web15 feb. 2013 · The Journal of Biological Chemistry Background: The tumor suppressor gene HIC1 (hypermethylated in cancer 1) encodes a transcriptional repressor SUMOylated at Lys-314. Results: DNA damage favors SUMOylation of HIC1 and its interaction with MTA1 to regulate the DNA repair process.
Hypermethylated in cancer 1
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Web25 jan. 2024 · Hypermethylated-in-Cancer 1 ( Hic1) is a tumor suppressor gene frequently inactivated by epigenetic silencing and loss-of-heterozygosity in a broad range of … WebAberrant DNA methylation is a hallmark of many cancers. Currently, there are four intrinsic molecular subtypes in breast cancer (BC): Luminal A, B, Her2-positive, and triple …
http://www.informatics.jax.org/marker/MGI:1338010 Web25 mei 2024 · HIC1 (Hypermethylated In Cancer 1 / HIC ZBTB Transcriptional Repressor 1) is a key transcriptional regulator that controls cell proliferation following DNA damage. …
WebGrowing evidence suggests that as a tumor suppressor gene, hypermethylated in cancer 1 (HIC1) is correlated with various malignancies in the modulation of tumor progression. This study aims to investigate the effect of HIC1 on regulating the proliferation, migration, and invasion of BCa. WebHIC1 is identified as novel E2F1 transcriptional target in DNA damage responses in cancer development and a set of transcription factors for regulation of a human HIC1 promoter reporter was screened. The Hypermethylated in Cancer 1 (HIC1) gene encodes a zinc finger transcriptional repressor that cooperates with p53 to suppress cancer development.
WebHIC1 (hypermethylated in cancer 1) is a tumor suppressor gene frequently epigenetically silenced in human cancers. HIC1 encodes a transcriptional repressor involved in the regulation of growth control and DNA damage response. We previously demonstrated that HIC1 can be either acetylated or SUMOylated on lysine 314.
Web14 apr. 2024 · Considering the distribution of the DM CpGs in relation to CpG islands, compared with the overall distribution of analyzed CpGs, we found enrichment for hypermethylated CpGs at CpG islands in the comparison of metastases with normal prostate samples [OR = 1.30, 95% confidence interval (CI) = 1.26–1.33, q < 2.22 × 10 … stylus for ipad 8th generationWeb7 aug. 2024 · The hypermethylation can be reverted using the FDA-approved DNMT inhibitor 5-aza-2'-deoxycytidine, also named 5-azacytidine or decitabine. 5-Azacytidine … stylus for hp touchscreen laptop amazonWeb5 apr. 2024 · As shown in Table 2, the pooled OR for BRCA1 promoter hypermethylation in breast cancer tissues was 4.312 (95% CI = 2.395–7.765, P < 0.001) compared with … pain and vein clinicWebHIC1 (Hypermethylated in Cancer 1), as it name implied, was originally isolated as a new candidate tumor suppressor gene located at 17p13.3 because it resides in a CpG island … stylus for ipad 2015Web10 apr. 2024 · The DMP function based on the limma algorithm ( da Silva Rodrigues et al., 2024) was used to find the differentially methylated sites between the two groups, classified as hypermethylated and hypomethylated, which presented values of p ≤ 0.005 and β > 5% for hypermethylated sites and p ≤ 0.005 and β < −5% for hypomethylated sites. stylus for hp pavilion 11 x2 notebookWebTwenty-two DNA repair genes with hypermethylated promoters, and reduced or absent expression, were found to occur among 17 types of cancer, as listed in two review … stylus for ipad amazonWeb22 jun. 2024 · CDH1, cadherin-1; HIC1, hypermethylated in cancer 1; M0, cancer has not spread to other parts of the body; M1, cancer has spread to other parts of the body; MLH1, MutL homolog-1; MX, metastasis occurred but cannot be measured; SFRP1, secreted frizzled related protein-1; TIMP3, TIMP metallopeptidase inhibitor-3; VIM, vimentin. stylus for ipad 8