WebMouse fetuses with disrupted Igf2 transcripts expressed exclusively by the labyrinthine trophoblast of the placenta (P0- Igf2) are growth restricted in late pregnancy such that at birth they weigh on average 31% less than their wild type litter mates [ 2 ]. Web1 nov. 2007 · In this study, we used Igf2 knockout (Igf2) neonate mice to determine whether Igf2 deficiency is detrimental to motor neuron survival after axonal injury.

Placental-specific Igf2 knockout mice exhibit hypocalcemia and …

Web1 nov. 2011 · Objectives. Deletion of the placental-specific P0 transcript of the insulin-like growth factor gene (Igf2) reduces placental growth from early pregnancy onwards.In Igf2 … Web1 nov. 2011 · This effect is specific to IGF-II as IGF-I knockout mice exhibit a similar placental size to WT mice [3]. IGF-II is only expressed by the paternal allele of the Igf2 … coedpoeth houses for sale

IGF2 knockout mice are resistant to kainic acid-induced seizures …

WebJ Physiol 586.20 (2008) pp 5023–5032 5023 Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse P. M. Coan … Web15 okt. 2024 · To assess whether mesenchymal Igf2 plays a role in controlling the early growth of the pancreas, Igf2 +/fl; Nkx3.2 Cre/+ knockout mice were first analysed at the … Web1 okt. 2009 · The IGF-II gene (igf2) is imprinted, showing paternal expression in the fetus and placenta [12]. Igf2+/− knockout mice manifest a 40% decrease in birth weight compared to their wt littermates [13] and have been used in a number of studies as a model for IUGR [13], [14]. Two igf2 mouse models are described in the literature. calvin klein south africa menlyn